蔡开勇教授系国家杰出青年科学基金获得者、教育部长江学者特聘教授、国家百千万人才工程入选者。该团队针对临床硬组织修复植入体抗炎症与感染，骨质疏松病患固定，以及药物响应性控释系统等实际需求开展研究，其主要研究方向集中在以下三个方面：

(1)钛及钛合金表/界面及其与细胞相互作用：从天然骨多级微/纳结构生物仿生角度出发，构筑钛基材多尺度微/纳复合结构界面及生物诱导性界面。探究钛基材表/界面介导特异蛋白吸附、细胞粘附/增殖/分化及组织形成的基本规律及分子机制。

(2)响应性纳米药物控释系统及微装置：利用铁磁纳米颗粒及介孔硅纳米颗粒，发展对不同外界刺激（如热、光、磁场、pH、氧化还原等）产生反应的响应性纳米药物递送系统，在分子、细胞和动物水平探究各系统载体的分解、代谢及分布，为临床肿瘤治疗提供潜在的载体及科学依据。

(3)功能性钛合金植入体研发关键技术：针对临床硬组织修复植入体(人工关节、种植牙等)潜在的炎症、细菌感染，骨质疏松病患固定等实际需求开展研究，发展抗菌/炎症及原位骨质疏松治疗新技术，为研发相关功能性钛合金植入体提供技术支撑。

该团队主要成员包括：蔡开勇教授（组长）、胡燕教授、杨维虎教授、刘鹏教授、漆超副教授、冯茜副教授、夏曾子露副教授、赵鹏副教授。

Professor Cai is a winner of the National Science Foundation for Outstanding Youth, a distinguished Professor of Cheung Kong Scholars of the Ministry of Education, and a member of the National Program for Millions of Talents. Cai group carried out research on the practical needs of clinical hard tissue repair implants for inflammation and infection, fixation for osteoporosis patients, and drug responsive controlled release system. The main research directions are focused on the following three aspects:

(1) The interaction of titanium and titanium alloy surface/interface with cells: Design and construction multi-scale micro/nano composite structure interface and bio-induced interface of titanium substrate from the biomimetic perspective of multi-scale micro/nano structure of natural bone. Systematic study the basic laws and molecular mechanisms of titanium substrate/interfacial mediated specific protein adsorption, cell adhesion/proliferation/differentiation, and tissue formation.

(2) Responsiveness of nano drug controlled release system and micro devices: Design and development of responsive drug deliverysystem to respond the different external stimuli (e.g. heat, light, magnetic field, pH, redox, etc.) by using ferromagnetic nanoparticles and mesoporous silica nanoparticles. Exploration the decomposition, metabolism and distribution of the each systems at the molecular, cellular and animal level to provide the potential carriers and scientific basis for clinical tumor treatment.

(3) The key technology of the research and development of functional titanium alloy implants: Development of new technology for anti-bacterial/inflammation and in situ osteoporosis treatment, provide technical support for the research and development of functional titanium alloy implants.

The main members of the team include: Professor Kaiyong Cai (Principal Investigator), Yan Hu (Professor), Weihu Yang (Professor), Peng Liu (Professor), Chao Qi (Associate professor), Qian Feng (Associate professor), and Zengzilu Xia (Associate professor).